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Efflux-Mediated Antimicrobial Resistance in Bacteria by Xian-Zhi Li download in iPad, ePub, pdf

Role of plasmidencoded drug

Antimicrobial drug efflux pumps in Staphylococcus aureus. Zgurskaya joined the faculty of the Department of Chemistry and Biochemistry at the University of Oklahoma. Her current research focuses on mechanisms of bacterial multidrug efflux pumps and permeability of Gram-negative outer membrane. Keith Poole in Canada, respectively. Antimicrobial drug efflux pumps in other Gram-positive bacteria.

AcrB transporter is a homotrimer, and characteristically contains a large periplasmic domain that equals the transmembrane domain in size. Hiroshi Nikaido and Queen's University. Furthermore, the so-called resistance island, often on a chromosome, may contain a cluster of multiple resistance genes. Williams and Queen's University, Kingston with Dr.

Antimicrobial drug efflux pumps in Stenotrophomona maltophilia. Antimicrobial drug efflux systems as components of bacterial stress responses. Antimicrobial resistance and drug efflux pumps in Vibrio and Legionella.

In this article, we cover the advances in bacterial efflux systems since with emphasis on the clinical relevance of the drug exporters in various bacteria. Antimicrobial resistance and drug efflux pumps in Bacteroides. Multidrug efflux pumps and their inhibitors characterized by computational modeling. Second, novel mechanisms of resistance with emerging resistance determinants have been reported. Li received his medical degree and a M.

The functionally rotating mechanism has also been further supported by recent biochemical studies with disulfide cross-linking as well as by the behaviour of covalently linked AcrB protomers. Antibacterial resistance continues to be a global public health concern, threatens the effectiveness of antibacterial therapy, and also challenges the efforts for developing novel antibacterials.

Structures and Mechanisms Bacterial drug efflux pumps have been categorized into five families, i. Role of plasmid-encoded drug efflux pumps in antimicrobial resistance.

Impact of antimicrobial drug efflux pumps on antimicrobial discovery and development. Antimicrobial drug efflux pump inhibitors. Antimicrobial resistance and drug efflux pumps in Helicobacter. Antimicrobial drug efflux pumps in Escherichia coli.

Antimicrobial development and efflux pump inhibitors. Antimicrobial drug efflux pumps in Salmonella.

Structures and Mechanisms Bacterial